HYPERHOMOCYSTEINEMIA IN CIRRHOSIS OF THE LIVER
Keywords:
Keywords: homocysteine, metabolism, liver, cirrhosis, vitamins B6, B12.Abstract
Abstract:Numerous clinical and epidemiological studies have identified
elevated plasma homocysteine levels as a risk factor for atherosclerotic vascular
diseases and thromboembolism. Hyperhomocysteinemia may develop due to defects in
genes that metabolize homocysteine; dietary conditions that lead to a deficiency of
vitamins B6, B12, or folic acid; or chronic alcohol use. Homocysteine is an
intermediate product of methionine metabolism, which occurs mainly in the liver.
Impaired liver function leads to changes in the metabolism of methionine and
homocysteine; however, the molecular basis of such changes is not fully understood.
In addition, the mechanisms of cellular toxicity caused by homocysteineare not fully
defined.
References
Literature
1. Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990; 1:
228–236.
2. Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular
disease. Annu Rev Medicine. 1998; 49: 31–62.
3. Mayer EL, Jacobsen DW, Robinson K. Homocysteine and coronary atherosclerosis.
J Am Coll Cardiol. 1996; 27: 517–527.
4. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake
as primary determinants of homocysteinemia in an elderly populations. J Am Med
Assoc. 1993; 270: 2693– 2698.
5. Mukhammadieva M.I. (2022). Modern Clinical and Biochemical Characteristics of
Liver Cirrhosis Patients of Viral Etiology with Spontaneous Bacterial Peritonitis
//Texas Journal of Medical Science. – 2022.- P. 86-90.
6. Oblokulov Abdurashid Rakhimovich Mukhammadieva Musharraf Ibrokhimovna
Sanokulova Sitora Avazovna Khadieva Dora Isakovna. (2023).CLINICAL AND
LABORATORY FEATURESOF SPONTANEOUS BACTERIAL PERITONITIS
IN PATIENTS WITH VIRAL LIVER CIRRHOSIS. Journal of Advanced Zoology,
44(S2), 3744–3750. from
http://www.jazindia.com/index.php/jaz/article/view/1716
7. Oblokulov A.A., Oblokulov A.R., Ergashov M.M. Clinical and laboratory criteria
for spontaneous bacterial peritonitis in liver cirrhosis of viral etiology. Central
Asian journal of medical and natural sciences Volume 03, Issue 03, may-jun 2022
172-177. ISSN: 2660-4159.
8. Ibrokhimovna, M. M. . (2024). Improvement of Primary Prophylaxis and Treatment
of Spontaneous Bacterial Peritonitis Complicated in Virus Etiology Liver Cirrhosis.
Journal of Intellectual Property and Human Rights, 3(4), 19–25. Retrieved from
http://journals.academiczone.net/index.php/jiphr/article/view/2506
9. Elmurodova A.A. (2023). Viral Hepatitis Delta: An Underestimated Threat. Texas
Journal of Medical Science, 26, 1–3. Retrieved from
https://zienjournals.com/index.php/tjms/article/view/4610
10. Oblokulov Abdurashid Rakhimovich Mukhammadieva Musharraf Ibrokhimovna
Sanokulova Sitora Avazovna Khadieva Dora Isakovna. (2023). CLINICAL AND
LABORATORY FEATURES OF SPONTANEOUS BACTERIAL PERITONITIS
IN PATIENTS WITH VIRAL LIVER CIRRHOSIS. Journal of Advanced Zoology,
44(S2), 3744–3750. from
http://www.jazindia.com/index.php/jaz/article/view/1716
11. Mukhammadieva M.I. (2022). Modern clinical and biochemical characteristics of
liver cirrhosis patients of viral etiology with spontaneous bacterial peritonitis
//Texas Journal of Medical Science. – 2022.- P. 86-90
12. Abdulloev Mukhriddin Ziyodulloevich. (2023). Modern Therapy of Viral Hepatitis.
Texas Journal of Medical Science, 26, 66–69. Retrieved from
https://www.zienjournals.com/index.php/tjms/article/view/4636
13. Abdulloev Mukhriddin Ziyodulloevich. (2023). Modern Therapy of Viral Hepatitis.
Texas Journal of Medical Science, 26, 66–69. Retrieved from
https://www.zienjournals.com/index.php/tjms/article/view/4636
14. Mukhammadieva M.I. (2023). Virus etiology : zhigar cirrhosis bemorlarida
spontaneous bacterial peritonitis bilan asoratlanishning prophylaxis ва davosini
takomillashtirish/ / Oriental Renaissance: Innovative, educational, natural and
social sciences. - 2023.-P.947-953.
15. Oblokulov A.R., M.I.Mukhammadieva.(2022). Clinical and biochemical
characteristics of liver cirrhosis patients of viral etiology with spontaneous bacterial
peritonitis//Academicia Globe: Indersciense Research.-2022.- P. 210-216.
16. M. R., M. ., & S. A., S. . (2022). Features of the Course of Contagious Giardiasis
Associated with Giardiasis. Miasto Przyszłości, 26, 186–189. Retrieved from
https://miastoprzyszlosci.com.pl/index.php/mp/article/view/464
17. Sanokulova Sitora Avazovna. (2023). COVID-19 IN CHILDREN. Academia
Science Repository, 4(06), 25–32. Retrieved from
https://academiascience.com/index.php/repo/article/view/843
18. Sanokulova Sitora Avazovna. (2023). Acute Kidney Injury in Critically Ill Cirrhotic
Patients with Spontaneous Bacterial Peritonitis. Texas Journal of Medical Science,
25, 65–70. Retrieved from
https://zienjournals.com/index.php/tjms/article/view/4502
1. 19.Sanokulova Sitora Avazovna. (2023). Factors of Development of Hepatorenal
Syndrome in Patients with Liver Cirrhosis of Viral Etiology. Texas Journal of
Medical Science, 26, 4–9.from
https://www.zienjournals.com/index.php/tjms/article/view/4611
19. Avazovna, S. S. (2023). Factors Of Development Of Hepatorenal Syndrome In
Patients With Cirrhosis Of The Liver Of Viral Etiology. AMALIY VA TIBBIYOT
FANLARI ILMIY JURNALI, 2(12), 1–8. Retrieved from
https://www.sciencebox.uz/index.php/amaltibbiyot/article/view/8673
20. Sanokulova, Sitora Avazovna FEATURES OF THE COURSE OF CONTAGIOUS
HELMINTHS ASSOCIATED WITH GIARDIASIS / / ORIENSS. 2023. №2.
URL:https://cyberleninka.ru/article/n/ocobennosti-techeniya-kontogioznyh-
gelmintov -assotsiirovannogo-s-lyambliozom (дата обращения: 12.12.2023).
21. Oblokulova Z.I, Oblokulov A.R, & Jalilova A.S. (2022). Diagnostic Significance
of Hepatic Fibrosis in Patients with Extrahepatic Chronic Viral Hepatitis C. Central
Asian Journal of Medical and Natural Science, 3(3), 438-443. Retrieved from
https://www.cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/806
22. Абдуллоев М. и др. Взгляд Инфекциониста На Течении Кора У Детей
//AMALIY VA TIBBIYOT FANLARI ILMIY JURNALI. – 2023. – Т. 2. – №. 12.
– С. 930-939.
23. Абдуллоев М. З. Особенности Течении Кори У Детей //Journal of Intellectual
Property and Human Rights. – 2024. – Т. 3. – №. 4. – С. 26-33.
24. Абдуллоев М. З. ВЕТРЯНАЯ ОСПА У ВЗРОСЛЫХ И ДЕТЕЙ //TA'LIM VA
RIVOJLANISH TAHLILI ONLAYN ILMIY JURNALI. – 2023. – Т. 3. – №. 12.
– С. 410-418.
25. Amirkulovna A. G. Clinical and Epidemiological Features of Measles in Adults
//Central Asian Journal of Medical and Natural Science. – 2022. – Т. 3. – №. 3. –
С. 80-86.
